ٍSynthesis of Laser-Sensitive Chromophores and their Attachement to an Antitumor Drug; Doxorubicin

Volume 14 , 2000, Pages: 061-081

ٍSynthesis of Laser-Sensitive Chromophores and their Attachement to an Antitumor Drug; Doxorubicin

Mohammed A. Al-Nuri

Department of Chemistry, Faculty of Science, An-Najah National Univesity, Nablus, Palestine

Received : 14-11-1999 , Accepted : 06-06-2000

Language: English

Abstract

Four highly conjugated laser-sensitive two-photon chromophores (9a; 9b; 9c; 9d) have been synthesized। Each chromophore has been attached to the anti-cancer drug, doxorubcin, to produce the labeled doxorubicins (12a; 12b; 12c; 12d) for imaging the biologic cellular processes. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D215

Electophysiological assessments of the effects of Glycemic events, Ascorbic acid and Thaimine, on the Peripheral Neuropathy of Diabetes Mellitus Patie

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 179-195

Electophysiological assessments of the effects of Glycemic events, Ascorbic acid and Thaimine, on the Peripheral Neuropathy of Diabetes Mellitus Patients

I.W.M. Al- Hasan*, G.A. Al- Sharify**

*Faculty of Pharmacy, An-Najah National University, Nablus, Palestine. **Al-Yarmouk Hospital, Baghdad

Received : 06-02-2001 , Accepted : 05-11-2001

Language: English

Abstract

Three groups of patients who had diabetes mellitus for 10 years were enrolled in the study and compared with the control group। Electrophysiological study on seven peripheral nerves were carried out once in the control subjects and four times in the diabetic patients; the first examination was conducted prior to drug supplement and the subsequent reexaminations conducted at the end of 6; 12 and 18 months following the drugs treatments, ascorbic acid (AA) and Thiamine (B1). The results indicate that improvements in latency, velocity and amplitude of the nerves evoked responses were significantly better with the use of AA compared to thiamine use in the patients. The results also show that the improvements were significantly greater in insulin dependent diabetes mellitus (IDDM) compared to that of non insulin dependent diabetes mellitus (NIDDM) patients with the presence of AA in both groups.Nevertheless the results indicate that with better glycemic control, the tested nerves show variable degrees of functional improvements detected by the three examined parameters at the end of the 6 and 12 months. At the end of the last visit (18 months after the first visit) more improvements were observed in the three parameters of IDDM patients. Key words: Ascorbic acid, Thiamine, Insulin, effectiveness, Diabetic Neuropathy. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D234

Spectrophotometric Determination of Tiopronin in Pharmaceutical Preparations

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 145-157

Spectrophotometric Determination of Tiopronin in Pharmaceutical Preparations

Maher Abu-Eid*, Nidal Zatar*, Tamara Kamal** and Mohammad Hannoun***

*Chemistry Department, Faculty of Science, **Drug Quality Control Unit, ***Faculty of Pharmacy, An-Najah N. University, Nablus, Palestine

Received : 09-10-2000 , Accepted : 07-05-2001

Language: English

Abstract

Two spectrophotometric methods are described for the determination of tiopronin in pharmaceuticals। They are based on the oxidation-reduction reaction between tiopronin and iron (III), then forming a complex between iron (II) and ferrozine or di-2-pyridyl ketone-2-thiophenoylhydrazone. The produced colored iron (II)-ferrozine complex [system I] absorbs at 562 nm, while the iron (II)-di-2-pyridyl ketone-2-thiophenoylhydrazone complex [system II] absorbs at 656 nm. The effect of different factors such as: pH, reagent concentration, time of reaction, temperature and the tolerance amount of the common excipients have been studied. Applying the optimum working conditions, tiopronin can be determined over the range 0.2-8.6 and 0.5-17.0 ppm and with molar absorptivities of 2.0x104 and 1.0x104 l mol-1cm-1 for systems I and II, respectively. Both methods offer high selectivity, sensitivity and accuracy with a relative standard deviation (RSD) of less than 1.1% for five measurements. The proposed methods were applied successfully for the determination of tiopronin in Captimer tablets. Key Words: Spectrophotometry, Tiopronin, Ferrozine, Di-2-pyridyl ketone-2-Thiophenoylhydrazone (DPKTH), Pharmaceutical analysis. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D232

A New Optimum Method for Designing Dredging System

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 159-178

A New Optimum Method for Designing Dredging System

Zaher Kuhail

Civil Engineering, Faculty of Engineering, Islamic University, Gaza, Palestine.

Received : 19-11-2000 , Accepted : 05-11-2001

Language: English

Abstract

The purpose of this paper is to try to reach a suitable design method for dredging systems, using a large amount of experimental data of the author and others। A theoretical model was derived and adopted, then tested against the chosen experimental data. The mostly used theories in sediment transport with special emphasis on pipe roughness have been investigated and compared with the proposed model. Different pipe roughness, pipe diameters, sediment parameters, and velocities have been studied and tested under different flow regimes and conditions (experimentally and theoretically). A flow regime index has been introduced by the author to allow different flow regimes to be distinguished (heterogeneous, saltation and critical flow regimes). At the end a new method of design has been introduced using the modified roughness transport parameter, which when tested against all data, a satisfactory correlation was reached. This parameter proved to be the best among all existing methods, with the best correlation, which enabled the introduction of a proper design method for dredging purposes. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D233

Polystyrene Lightweight Concrete (Polyconcrete)

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 041-061

Polystyrene Lightweight Concrete (Polyconcrete)

Zaher Kuhail

Civil Engineering Department, Islamic University, Gaza, Palestine.

Received : 21-02-2000 , Accepted : 18-07-2001

Language: English

Abstract

This paper handles the characteristics of new lightweight concrete consisting of polystyrene, sand, cement and water। Through this paper it has been proven that the proposed mix is very reliable giving strengths of up to 200 kg/cm2 with a low density. The mechanical and chemical properties are discussed in order to study the behaviour of the polystyrene under different environments (i.e. field usage). The mix workability is very high at a very low water/cement ratio (down to 0.35). This work can be considered a new line of research for lightweight concrete as the mixing method is very simple, relatively inexpensive and does not need complex machinery systems. http://www.najah.edu/

Oxidation of some Alicyclic Amines by Potassium Hexacyanoferrate (III) in Alkaline Medium: A Kinetic and Mechanistic Study

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 029-039

Oxidation of some Alicyclic Amines by Potassium Hexacyanoferrate (III) in Alkaline Medium: A Kinetic and Mechanistic Study

M. M. Al-Subu, A. A. Amer, W. J. Jondi, M. Hanoun, M. J. Musmar

a Dept. of Chem., b College of Pharmacy, An-Najah N. Univ. Nablus, Palestine.

Received : 14-02-2001 , Accepted : 13-06-2001

Language: English

Abstract

Oxidation of some alicyclic amines (morpholine, piperazine and piperidine) by potassium hexacyanoferrate(???) in basic medium has been investigated at 35°C। Stoichiometric results showed that four moles of hexacyanoferrate(III) were consumed per mole of piperidine or morpholine whereas piperazine consumed eight moles of the oxidant to produce the corresponding lactams. Kinetic studies indicated that piperidine and morpholine also followed different kinetics from that of piperazine, being first order in the amine concentration and independent of the concentrations of hexacyanoferrate(???) and hydroxide ion, while in the case of piperazine, the reaction was first order in both oxidant and substrate concentrations and zero order with respect to the concentration of hydroxide ion. The changes in reaction rate due to changing ionic strength of the medium as well as other factors has also been investigated. The activation parameters of the oxidation process have been evaluated and a mechanism consistent with the observed kinetics has been proposed. Keywords: Hexacyanoferrate(???), morpholine, piperazine, piperidine, oxidation, lactam. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D225

On Multipliers of Orlicz Spaces

An-Najah University Journal for Research - Natural Sciences (A) ISSN: 1727-2114

Volume 15 , 2001, Pages: 001-009

On Multipliers of Orlicz Spaces

Mahmud Masri

Mathematics Department, An-Najah National University, Nablus, Palestine

Received : 09-10-2000 , Accepted : 07-05-2001

Language: English

Abstract

Let be a finite positive measure space, X a Banach space, a modulus function and a strongly measurable function। The Orlicz space is. The space of Bochner p-integrable functions, is.Also,. When X is a Banach algebra we show that the multipliers of is if for all a1 and b.Also, = if for all a,b in [0,which generalizes the special case X being the complex numbers C. When is also non-atomic we show that for all iff. http://www.najah.edu/index.php?page=2149&l=en&extra=%26id%3D222